Final Accepted Version Lcmp-00388-2002.r2 Expression of Vegf and Its Receptors Flt-1 and Flk-1/kdr Are Altered in Lambs with Increased Pulmonary Blood Flow and Pulmonary Hypertension
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Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension.
Utilizing in utero aortopulmonary vascular graft placement, we developed a lamb model of congenital heart disease and increased pulmonary blood flow. We showed previously that these lambs have increased pulmonary vessel number at 4 wk of age. To determine whether this was associated with alterations in VEGF signaling, we investigated vascular changes in expression of VEGF and its receptors, Flt...
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